ncRNA basic information
ncRNA ID:
MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b-2
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
the mitochondrial pathway of apoptosis
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by real-time quantification RT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Caspase-3 activation status was measured using the Caspase-Glo 3 Assay .
Drug Response:
resistant
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
tissue and cell line
Other information
Title:
MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis.
Journal:
Int J Oncol
Published:
2012
PubMed ID:
21879257