ncRNA basic information
ncRNA ID: MI0000270/MI0000683
ncRNA Database: miRBase
ncRNA Name: miR-181b
ncRNA Type: miRNA
ncRNA Expression: up-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: EGFR
ncRNA Pathway: EGFR pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00853 (APRD00557)
Drug Name: Temozolomide
Drug Method: In this study, quantitative real-time reverse transcription PCR (qRT-PCR) data indicated that miR-181b was significantly downregulated in recurrent GBM tissues compared with initial GBM tissues. We also found that miR-181b overexpression increased the chemo-sensitivity of GBM cells to TMZ and potentiated TMZ-induced apoptosis in vitro and in vivo. Moreover, we demonstrated that the epidermal growth factor receptor (EGFR) was a direct target of miR-181b: restoration of EGFR rescued the inhibitory effects of miR-181b and TMZ treatment.
Drug Response: sensitive
Cancer basic information
Cancer: glioblastoma multiforme
Tissue/Cell: cell line ( U87, U251, HEK293T)
Other information
Title: MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor.
Journal: J Neurooncol
Published: 2017
PubMed ID: 28501897