ncRNA basic information
ncRNA ID:
MI0003138
ncRNA Database:
miRBase
ncRNA Name:
miR-497
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
BCL2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901,SGC7901/VCR,A549,A549/CDDP)
Other information
Title:
miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2.
Journal:
Med Oncol
Published:
2012
PubMed ID:
21258880