ncRNA basic information
ncRNA ID: NA
ncRNA Database: miRBase
ncRNA Name: miR-19
ncRNA Type: miRNA
ncRNA Expression: down-regulated
ncRNA Method: RT-PCR, qRT-PCR
ncRNA Target Gene: PTEN
ncRNA Pathway: NA
Evidence (ncRNA-drug): predicted
drug basic information
Drug ID: DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name: Paclitaxel
Drug Method: We analyzed miRNA expression levels in three MDR cell lines in comparison with their parent cell line, MCF-7, using a miRNA microarray. We investigated whether inhibitor of miR-19 sensitized MDR cells to chemotherapeutic agents in vitro and in vivo.
Drug Response: sensitive
Cancer basic information
Cancer: breast cancer
Tissue/Cell: cell line (MCF-7/TX200, MCF-7/VP-16, MCF-7/MX100,MCF7/WT,MCF-7/VP)
Other information
Title: Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN.
Journal: Pharm Res
Published: 2011
PubMed ID: 21853360