ncRNA basic information
ncRNA ID:
MI0000434
ncRNA Database:
miRBase
ncRNA Name:
Let-7i
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
ER-alpha36 mediated nongenomic estrogen signal pathways
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The expression levels of miRNA were determined by Quantitative Real-Time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (184A1,MEGM,MCF7, ZR-75-1, T47D, HB3396,MDA-MB-231, MDA-MB-436, MDA-MB-468, SK-BR-3,MCF7)
Other information
Title:
let-7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor alpha signaling in breast cancer.
Journal:
Mol Med
Published:
2011
PubMed ID:
21826373