ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
miRBase
ncRNA Name:
let-7
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
ER-alpha36 mediated nongenomic estrogen signal pathways
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The role of let-7 in breast cancer cells was detected using quantitative Real-Time PCR, Western blot, MTT assay, Luciferase assay,etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line(184A1,MCF7,ZR-75-1, T47D and HB3396)
Other information
Title:
let-7 MicroRNAs Induce Tamoxifen Sensitivity by Downregulation of Estrogen Receptor alpha Signaling in Breast Cancer
Journal:
Mol Med
Published:
2011
PubMed ID:
21826373