ncRNA basic information
ncRNA ID:
MI0000442
ncRNA Database:
miRBase
ncRNA Name:
miR-122
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells .Flow cytometry analysis of cell apoptosis and f cell cycle distribution .
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (Hep3B, HepG2, Huh7, PLC/PRF/5,HEK293)
Other information
Title:
MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest.
Journal:
Cancer Lett
Published:
2011
PubMed ID:
21802841