ncRNA basic information
ncRNA ID:
MI0003139
ncRNA Database:
miRBase
ncRNA Name:
miR-181d
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Rap1B
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by Real-time quantitative PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by transwell migration .
Drug Response:
sensitive
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (U251, U87)
Other information
Title:
miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells.
Journal:
Med Oncol
Published:
2014
PubMed ID:
24573637