ncRNA basic information
ncRNA ID:
MI0000459
ncRNA Database:
miRBase
ncRNA Name:
miR-143
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR,RT-PCR
ncRNA Target Gene:
IGF1R,BCL2
ncRNA Pathway:
IGF1R signal pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
miR-143 was detected by quantitative real-time PCR. Cisplatin resistance changes of cells was tested via MTT assay. Target genes of miR-143 were verified by dual-luciferase activity assay. Immunohistochemistry, immunofluorescence staining, Western blot, cell proliferation, and clonogenic and apoptosis assay were used to elucidate the mechanism of miR-143 in cisplatin resistance formation.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line ( GES-1, MKN45, MGC803, BGC823, SGC7901,SGC7901/DDP)
Other information
Title:
Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2.
Journal:
Tumour Biol
Published:
2015
PubMed ID:
25492481