ncRNA basic information
ncRNA ID:
MI0000098
ncRNA Database:
miRBase
ncRNA Name:
miR-96
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
RAD51 and REV1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-96 in human cancer cells was detected using Immunofluorescence microscopy, western blot analysis, Real-time PCR,cell cycle analysis,homologous recombination (HR) assay, crystal violet assay, clonogenic survival assay,xenograft mice study,etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
cancer
Tissue/Cell:
cell line (U2OS, HeLa, HCC1937, MDA-MB-231,HCT116,PEO1,PEO1 C4-2)
Other information
Title:
MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition.
Journal:
Cancer Res
Published:
2012
PubMed ID:
22761336