ncRNA basic information
ncRNA ID:
MIMAT0000690
ncRNA Database:
miRBase
ncRNA Name:
miR-296-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Three cisplatin resistant sublines (NTERA-2-R, NCCIT-R, 2102EP-R) showing 2.7-11.3-fold increase in drug resistance after intermittent exposure to increasing doses of cisplatin were compared to their parental counterparts, three well established relatively cisplatin sensitive germ cell tumor cell lines (NTERA-2, NCCIT, 2102EP). Cells were cultured and total RNA was isolated from all 6 cell lines in three independent experiments. RNA was converted into cDNA and quantitative RT-PCR was run using 384 well low density arrays covering almost all (738) known microRNA species of human origin.
Drug Response:
resistant
Cancer basic information
Cancer:
germ cell tumor
Tissue/Cell:
cell line
Other information
Title:
Micro-RNA expression in cisplatin resistant germ cell tumor cell lines.
Journal:
Mol Cancer
Published:
2011
PubMed ID:
21575166