ncRNA basic information
ncRNA ID:
ENSG00000203875
ncRNA Database:
Ensembl
ncRNA Name:
SNHG5
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We detected the expressions of SNHG5, apoptosis-specific genes (Bax and Bcl-2) and drug resistance-specific genes (MDR1 and MRP1) in cisplatin-sensitive and cisplatin-resistant GC patients. The expression levels were also detected in cisplatin-resistant GC cell lines (BGC823/DDP, SGC7901/DDP) and GC cell lines (BGC823 and SGC7901). Through the liposome transfection, the regulatory effects of SNHG5 on proliferative potential and apoptosis were examined by cytotoxicity assay and flow cytometry assay, respectively. The protein levels of apoptosis-related genes and drug resistance-related genes influenced by SNHG5 were detected by Western blot.
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (BGC823, SGC7901,BGC823/DDP, SGC7901/DDP)
Other information
Title:
LncRNA SNHG5 promotes cisplatin resistance in gastric cancer via inhibiting cell apoptosis.
Journal:
Eur Rev Med Pharmacol Sci
Published:
2019
PubMed ID:
31173289