ncRNA basic information ncRNA ID: ENSG00000278924 ncRNA Database: Ensembl ncRNA Name: lncRNA-AC078883.3 ncRNA Type: lncRNA ncRNA Expression: down-regulated ncRNA Method: RT-PCR ncRNA Target Gene: PTEN ncRNA Pathway: PTEN/AKT pathway Evidence (ncRNA-drug): validated

drug basic information Drug ID: DB00515 (APRD00359) Drug Name: Cisplatin Drug Method: This study aimed to investigate the potential role of lncRNA-AC078883.3 in the development of chemoresistance against cisplatin. Real-time PCR, Western blot analysis, Immunohistochemistry (IHC) assay, bioinformatic analysis, and luciferase assay were collaboratively used to establish the lncRNA-AC078883.3/miR-19a/PTEN/AKT pathway. Also, the effect of cisplatin on cell proliferation was observed via an MTT assay. Furthermore, Cox regression and Kaplan-Meier analyses were used to study whether lncRNA-AC078883.3 is involved in the survival of NSCLC. Drug Response: resistant

Cancer basic information Cancer: lung non-small cell carcinoma Tissue/Cell: cell line (A549 and H460)

Other information Title: Deregulation of lncRNA-AC078883.3 and microRNA-19a is involved in the development of chemoresistance to cisplatin via modulating signaling pathway of PTEN/AKT. Journal: J Cell Physiol Published: 2019 PubMed ID: 31111480