ncRNA basic information
ncRNA ID:
ENSG00000229807
ncRNA Database:
Ensembl
ncRNA Name:
XIST
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PDCD4 and Fas-L
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Realtime PCR was performed to detect the expression of XIST in cisplatin-resistant human nasopharyngeal carcinoma cell line HNE1/DDP. The effects of up-regulation and down-regulation of XIST on DDP resistance, proliferation and apoptosis of HNE1/ DDP cells were assessed using MTT assay, EdU assay and flow cytometry. Western blotting was used to detect the changes in the expressions of programmed cell death 4 (PDCD4) and Fas ligand (Fas-L) proteins in the cells in response to up-regulation or down-regulation of XIST.
Drug Response:
sensitive
Cancer basic information
Cancer:
nasopharyngeal carcinoma
Tissue/Cell:
cell line (HNE1,HNE1/DDP)
Other information
Title:
Long non-coding RNA XIST modulates cisplatin resistance by altering PDCD4 and Fas-Lexpressions in human nasopharyngeal carcinoma HNE1 cells in vitro
Journal:
Nan Fang Yi Ke Da Xue Xue Bao
Published:
2019
PubMed ID:
31068307