ncRNA basic information
ncRNA ID:
ENST00000425894
ncRNA Database:
Ensembl
ncRNA Name:
GBCDRlnc1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
GBCDRlnc1/PGK1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
We established doxorubicin (Dox)-resistant gallbladder cancer cells and used microarray analysis to compare the expression profiles of lncRNAs in Dox-resistant gallbladder cancer cells and their parental cells. Knockdown or exogenous expression of lncRNA combined with in vitro and in vivo assays were performed to prove the functional significance of lncRNA. The effects of lncRNA on autophagy were assessed by stubRFP-sensGFP-LC3 and western blot. We used RNA pull-down and mass spectrometry analysis to identify the target proteins of lncRNA.
Drug Response:
sensitive
Cancer basic information
Cancer:
gallbladder cancer
Tissue/Cell:
cell line (NOZ,GBC-SD,NOZ/Dox and GBC-SD/Dox)
Other information
Title:
Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy.
Journal:
Mol Cancer
Published:
2019
PubMed ID:
30953511