ncRNA basic information
ncRNA ID:
NR_026774.1
ncRNA Database:
RefSeq
ncRNA Name:
LINC00239
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
PI3K/Akt/mTOR pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The role of linc00239 in acute myeloid leukaemia cells was detected using RT-qPCR, CCK-8 assay, colony formation on soft agar, CFSE/PI staining, AnnexinV-FITC/PI staining, TUNEL staining and western blotting, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line (HL-60,KG-1)
Other information
Title:
Long non-coding RNA linc00239 promotes malignant behaviors and chemoresistance against doxorubicin partially via activation of the PI3K/Akt/mTOR pathway in acute myeloid leukaemia cells.
Journal:
Oncol Rep
Published:
2019
PubMed ID:
30720129