ncRNA basic information
ncRNA ID:
ENSG00000214049
ncRNA Database:
Ensembl
ncRNA Name:
UCA1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR,RT-qPCR
ncRNA Target Gene:
p21
ncRNA Pathway:
PI3K/AKT signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The role of UCA1 in breast cancer cells was detected using RT-PCR, WST-1 assay, flow cytometry for cell cycle and apoptosis analysis, RNA immunoprecipitation (RIP) assay, chromatin immunoprecipitation (ChIP) assay and western blot, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,T47D,LCC2, LCC9)
Other information
Title:
Long non-coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway.
Journal:
Int J Oncol
Published:
2019
PubMed ID:
30628639