ncRNA basic information
ncRNA ID:
ENSG00000253552
ncRNA Database:
Ensembl
ncRNA Name:
HOXA-AS2
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
HOXA3
ncRNA Pathway:
HOXA3/EGFR/Ras/Raf/MEK/ERK pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
NA
Drug Name:
Glucocorticoid
Drug Method:
The role of HOXA-AS2 in acute lymphoblastic leukemia cells was detected using quantitative real-time PCR, western blot, chromatin immunoprecipitation assay, Pull-down assay and mass spectrometry, Luciferase reporter assay, CCK-8 assay and cell apoptosis assay,etc.
Drug Response:
resistant
Cancer basic information
Cancer:
acute lymphocytic leukemia
Tissue/Cell:
cell line ( CCRF-CEM, Jurkat and CEM/C1)
Other information
Title:
TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway.
Journal:
Biomed Pharmacother
Published:
2019
PubMed ID:
30551418