ncRNA basic information
ncRNA ID:
ENSG00000247556
ncRNA Database:
Ensembl
ncRNA Name:
OIP5-AS1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
LPAATBeta
ncRNA Pathway:
LPAATBeta/PI3K/AKT/mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of OIP5-AS1 in osteosarcoma cells was detected using qPCR, CCK-8 assays, apoptosis assays, western blot analysis, Tumorigenicity assays in nude mice, Bioinformatics prediction and luciferase reporter assays,etc.
Drug Response:
resistant
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (MG63,SaOS2,MG63-CR,SaOS2-CR)
Other information
Title:
Long noncoding RNA OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATBeta/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p.
Journal:
J Cell Biochem
Published:
2019
PubMed ID:
30548308