ncRNA basic information
ncRNA ID:
ENSG00000214548
ncRNA Database:
Ensembl
ncRNA Name:
MEG3
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
PI3K/mTOR pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of MEG3 in T-cell lymphoblastic lymphoma cells was detected using quantitative real-time PCR, wound healing assay, invasion and migration assays, western blot analysis and Jurkat cells xenograft model, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
precursor T-lymphoblastic lymphoma/leukemia
Tissue/Cell:
cell line (Jurkat and SUP-T1)
Other information
Title:
MEG3 affects the progression and chemoresistance of T-cell lymphoblastic lymphoma by suppressing epithelial-mesenchymal transition via the PI3K/mTOR pathway.
Journal:
J Cell Biochem
Published:
2018
PubMed ID:
30556337