ncRNA basic information
ncRNA ID:
ENSG00000130600
ncRNA Database:
Ensembl
ncRNA Name:
H19
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
NA
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00947 (APRD00654)
Drug Name:
Fulvestrant
Drug Method:
Here we utilized established ETR cell models; the Tamoxifen (Tam)-resistant LCC2 and the Fulvestrant and Tam cross-resistant LCC9 cells. Gain and loss of H19 function were achieved through lentiviral transduction as well as pharmacological inhibitors of the Notch and c-Met receptor signaling pathways. The effects of altered H19 expression on cell viability and ETR were assessed using three-dimensional (3D) organoid cultures and 2D co-cultures with low passage tumour-associated fbroblasts (TAFs).
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( LCC2,LCC9, T-47D )
Other information
Title:
Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER+ Breast Cancer Cells.
Journal:
Cell Physiol Biochem
Published:
2018
PubMed ID:
30497079