ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
Ensembl
ncRNA Name:
D63785
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
MEF2D
ncRNA Pathway:
miR-422a-MEF2D signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of lncRNA were determined by Real-Time qPCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by transwell migration .Human tumor-bearing nude mice was used to test the role of D63785 and miR-422a .
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
tissue and cell lines (GES-1, SGC7901, MGC803, BGC823, NCI-N87,HEK293 and HEK293T)
Other information
Title:
The Long Noncoding RNA D63785 Regulates Chemotherapy Sensitivity in Human Gastric Cancer by Targeting miR-422a.
Journal:
Mol Ther Nucleic Acids
Published:
2018
PubMed ID:
30195778