ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
HOTAIR expression in OSCC cells was knocked down by small RNA interference. Transmission electron microscope, Western blot, and flow cytometry assay were used to detect the level of autophagy and apoptosis. OSCC cells were medicated with cisplatin, and median lethal dose (LD50) was performed to evaluate the effect on chemosensitivity of HOTAIR.
Drug Response:
sensitive
Cancer basic information
Cancer:
oral squamous cell carcinoma
Tissue/Cell:
cell line (KB,CAL-27)
Other information
Title:
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Journal:
J Oral Pathol Med
Published:
2018
PubMed ID:
30053324