ncRNA basic information
ncRNA ID:
MI0000448
ncRNA Database:
miRBase
ncRNA Name:
miR-130a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
RUNX3
ncRNA Pathway:
Wnt/Beta-catenin pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time polymerase chain reaction (PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Cell proliferation assays were performed by using Cell Counting Kit-8.
Drug Response:
resistant
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (Huh7, HEK 293)
Other information
Title:
Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell.
Journal:
Biochem Biophys Res Commun
Published:
2012
PubMed ID:
22846564