ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
EMT and the Beta-catenin pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00317 (APRD00997, DB07998)
Drug Name:
Gefitinib
Drug Method:
The expression levels of lncRNA were determined by Reverse transcription and quantitative real-time polymerase chain reaction . Those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of lncRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. Orthotopic nude mouse model and treatment was used to test the role of HOTAIR .
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (95C, 95D and YTMLC-90)
Other information
Title:
HOTAIR, a long noncoding RNA, is a marker of abnormal cell cycle regulation in lung cancer.
Journal:
Cancer Sci
Published:
2018
PubMed ID:
30047193