ncRNA basic information
ncRNA ID:
ENSG00000224078
ncRNA Database:
Ensembl
ncRNA Name:
lncRNA-SNHG14
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
Bcl-2/Bax apoptosis signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
Trastuzumab-resistant cell lines were established by continuously grafting HER2+ SKBR-3 and BT474 cells into trastuzumab-containing culture medium.Tn lncRNA microarray assay followed by reverse transcription-quantitative polymerase chain reaction analysis to identify that the different express of ncRNA in cell lines .Functional experimentation demonstrated that knockdown of lncRNA-SNHG14 potently promoted trastuzumab-induced cytotoxicity.The Signal Transduction Reporter Array indicated that lncRNA-SNHG14 may promote the effect of trastuzumab by targeting the apoptosis regulator Bcl-2 (Bcl-2)/apoptosis regulator BAX (Bax) signaling pathway.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( SKBR-3 and BT474)
Other information
Title:
Exosome-mediated transfer of lncRNA-SNHG14 promotes trastuzumab chemoresistance in breast cancer.
Journal:
Int J Oncol
Published:
2018
PubMed ID:
30015837