ncRNA basic information
ncRNA ID:
ENSG00000214049
ncRNA Database:
Ensembl
ncRNA Name:
UCA1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
Wnt and mTOR pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB11672
Drug Name:
Curcumin
Drug Method:
Different concentrations of curcumin were exposed to A549 cells for 24 h and cell viability was measured by CCK-8 assay. The expression of UCA1 was overexpressed in A549 cells by transfection with pEX-UCA1. Cell proliferation was determined by BrdU staining and assessing the expression of CyclinD1 using western blot and RT-PCR assay. Apoptotic cells were measured by flow cytometry assay. Western blot was performed to assess the expression of apoptosis-related, Wnt and mTOR pathways-related factors.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549)
Other information
Title:
Curcumin inhibits proliferation and enhances apoptosis in A549 cells by downregulating lncRNA UCA1.
Journal:
Pharmazie
Published:
2018
PubMed ID:
30001775