ncRNA basic information
ncRNA ID:
ENSG00000237424
ncRNA Database:
Ensembl
ncRNA Name:
FOXD2-AS1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ABCC3
ncRNA Pathway:
FOXD2-AS1/miR-143/ABCC3
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00441 (APRD00201)
Drug Name:
Gemcitabine
Drug Method:
The expression levels of lncRNA were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis.Fuciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by transwell invasion assay.Xenograft tumor model was used to test the role of FOXD2-AS1 and miR-143 .
Drug Response:
sensitive
Cancer basic information
Cancer:
bladder cancer
Tissue/Cell:
cell line (T24, 5637)
Other information
Title:
Long noncoding RNA FOXD2-AS1 accelerates the gemcitabine-resistance of bladder cancer by sponging miR-143.
Journal:
Biomed Pharmacother
Published:
2018
PubMed ID:
29674277