ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ULK1
ncRNA Pathway:
ULK1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB08865 (DB08700)
Drug Name:
Crizotinib
Drug Method:
In order to discover different expressions of lncRNA , we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2819/PTX . The expression levels of lncRNA were determined by Real-time PCR . BLAST is used to select the sequence that were complementary or similarity to the differentially expressed lncRNA sequence using the human mRNA database . Then, RNAplex was used to calculate the complementary energy between two sequences . TFurthermore, we conducted the lncRNA-mRNA co-expression network to predict the potential multidrug resistant lncRNAs'targets.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549, H460, H1299, NCI-H460, HCC-827,HBEC)
Other information
Title:
Silencing of LncRNA-HOTAIR decreases drug resistance of Non-Small Cell Lung Cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1.
Journal:
Biochem Biophys Res Commun
Published:
2018
PubMed ID:
29470986