ncRNA basic information
ncRNA ID:
ENSG00000249859
ncRNA Database:
Ensembl
ncRNA Name:
PVT1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
intrinsic apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In order to discover different expressions of lncRNA , we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2816/PTX . The expression levels of lncRNA were determined by Real-time PCR . BLAST is used to select the sequence that were complementary or similarity to the differentially expressed lncRNA sequence using the human mRNA database . Then, RNAplex was used to calculate the complementary energy between two sequences . TFurthermore, we conducted the lncRNA-mRNA co-expression network to predict the potential multidrug resistant lncRNAs'targets.
Drug Response:
resistant
Cancer basic information
Cancer:
colorectal cancer
Tissue/Cell:
tissue and cell line (HT29, SW480, HCT116, RKO, LoVo, NCM460)
Other information
Title:
Silencing long noncoding RNA PVT1 inhibits tumorigenesis and cisplatin resistance of colorectal cancer.
Journal:
Am J Transl Res
Published:
2018
PubMed ID:
29423000