ncRNA basic information
ncRNA ID:
ENSG00000214049
ncRNA Database:
Ensembl
ncRNA Name:
UCA1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
In order to discover different expressions of lncRNA , we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2815/PTX . The expression levels of lncRNA were determined by Real-time PCR . BLAST is used to select the sequence that were complementary or similarity to the differentially expressed lncRNA sequence using the human mRNA database . Then, RNAplex was used to calculate the complementary energy between two sequences . TFurthermore, we conducted the lncRNA-mRNA co-expression network to predict the potential multidrug resistant lncRNAs'targets.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( SKBR-3)
Other information
Title:
Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1.
Journal:
Biochem Biophys Res Commun
Published:
2018
PubMed ID:
29408336