ncRNA basic information
ncRNA ID:
ENSG00000243766
ncRNA Database:
Ensembl
ncRNA Name:
HOTTIP
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In order to discover different expressions of lncRNA , we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2812/PTX . The expression levels of lncRNA were determined by Real-time PCR . BLAST is used to select the sequence that were complementary or similarity to the differentially expressed lncRNA sequence using the human mRNA database . Then, RNAplex was used to calculate the complementary energy between two sequences . TFurthermore, we conducted the lncRNA-mRNA co-expression network to predict the potential multidrug resistant lncRNAs'targets.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung small cell carcinoma
Tissue/Cell:
tissue and cell line (H69, H69AR, H446, H446AR SCLC,NCI-H446,H446AR)
Other information
Title:
Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a.
Journal:
Cell Death Dis
Published:
2018
PubMed ID:
29367594