ncRNA basic information
ncRNA ID:
ENSG00000253438
ncRNA Database:
Ensembl
ncRNA Name:
PCAT-1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In order to discover different expressions of lncRNA , we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2808/PTX . The expression levels of lncRNA were determined by Real-time PCR . BLAST is used to select the sequence that were complementary or similarity to the differentially expressed lncRNA sequence using the human mRNA database . Then, RNAplex was used to calculate the complementary energy between two sequences . TFurthermore, we conducted the lncRNA-mRNA co-expression network to predict the potential multidrug resistant lncRNAs'targets.
Drug Response:
sensitive
Cancer basic information
Cancer:
oesophageal cancer
Tissue/Cell:
cell line (KYSE30, KYSE450, and Eca109)
Other information
Title:
LncRNA PCAT-1 promotes tumour growth and chemoresistance of oesophageal cancer to cisplatin.
Journal:
Cell Biochem Funct
Published:
2018
PubMed ID:
29314203