ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
PI3K/Akt and Wnt/Beta-catenin signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of HOTAIR and miR-34a in gastric cancer cells was detected using MTT assay, quantitative real-time PCR, Dual-luciferase report assay, RIP assay, caspase-3 activity detection and western blot , etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
tissue and cell line (SGC7901,MGC803,GES1,SGC7901/DDP)
Other information
Title:
Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/Beta-catenin signaling pathways by up-regulating miR-34a.
Journal:
Int J Biol Macromol
Published:
2018
PubMed ID:
29080815