ncRNA basic information
ncRNA ID:
MI0000476/MI0000455
ncRNA Database:
miRBase
ncRNA Name:
miR-138
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-Time qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
nucleotide excision repair (NER) pathway
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
MiRNA microarray was used to analyze the miRNA expression profiles in A549 cell line and its drugresistant counterpart, A549/DDP cell line.The expression levels of miRNA were determined by Real-Time Quantitative RT-PCR and RT-PCR . Those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549,A549/DDP)
Other information
Title:
Alterations of microRNAs in cisplatin-resistant human non-small cell lung cancer cells (A549/DDP).
Journal:
Exp Lung Res
Published:
2011
PubMed ID:
21787234