ncRNA basic information
ncRNA ID:
ENSG00000259974
ncRNA Database:
Ensembl
ncRNA Name:
LINC00261
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
Wnt/Beta-catenin pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Cell migration was detected by transwell migration and invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
colon cancer
Tissue/Cell:
tissue and cell line ( HCT116, HCT8, HT29, SW480,FHC)
Other information
Title:
Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy.
Journal:
Braz J Med Biol Res
Published:
2017
PubMed ID:
29267503