ncRNA basic information
ncRNA ID: NA
ncRNA Database: Ensembl
ncRNA Name: RP11-770J1.3
ncRNA Type: lncRNA
ncRNA Expression: down-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: MRP, BCRP, BCRP, and MDR/p-gp
ncRNA Pathway: NA
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name: Paclitaxel
Drug Method: The expression of lncRNA RP11-770J1.3 and TMEM25 in human breast cancer MCF-7(paclitaxel sensitive) and MCF-7/PR(paclitaxel resistant) cells were detected by quantitative RT-PCR. The synthetic interfering fragments of lncRNA RP11-770J1.3 and TMEM25 were transfected into MCF-7/PR cells. Sulforhodamine B assay was used to detect the sensitivity of MCF-7/PR cells to paclitaxel after interference of lncRNA RP11-770J1.3 and TMEM25. The expression of multidrug-resistance genes and proteins were detected by qRT-PCR and Western blot, respectively.
Drug Response: sensitive
Cancer basic information
Cancer: breast cancer
Tissue/Cell: cell line (MCF-7,MCF-7/PR)
Other information
Title: Effects of lncRNA RP11-770J1.3 and TMEM25 expression on paclitaxel resistance in human breast cancer cells
Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban
Published: 2017
PubMed ID: 29256224