ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00544 (APRD00516, EXPT03204)
Drug Name:
Fluorouracil
Drug Method:
We investigated the lncRNA expression level in GC tissues and normal gastric mucosa tissues by lncRNA chips analysis. The expression of lncRNA HOTAIR was detected by quantitative real time polymerase chain reaction (qRT-PCR). The relationship between HOTAIR expression level and prognosis was investigated by analyzing clinical samples. The influence of HOTAIR downregulation on GC cell proliferation, chemosensitivity, apoptosis, and invasion were determined by bromodeoxyuridine (BrdU) incorporation assay, flow cytometry analysis, and transwell assay. Tumor xenograft model was developed to study the influence of downregulated HOTAIR on tumor growth and metastasis.
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line ( BGC-823 and MKN-45)
Other information
Title:
Effect and mechanism of long noncoding RNAs HOTAIR on occurrence and development of gastric cancer.
Journal:
J Cell Biochem
Published:
2017
PubMed ID:
29236333