ncRNA basic information
ncRNA ID:
uc.57
ncRNA Database:
UCSC
ncRNA Name:
uc.57
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
BCL11A
ncRNA Pathway:
PI3K/AKT and MAPK signaling pathways
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells .Tumor xenograft and tumorigenicity assay was used to test the role of uc.57 .
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MCF-7,MCF-7R)
Other information
Title:
Shikonin reduces tamoxifen resistance through long non-coding RNA uc.57.
Journal:
Oncotarget
Published:
2017
PubMed ID:
29179465