ncRNA basic information
ncRNA ID:
ENSG00000240498
ncRNA Database:
Ensembl
ncRNA Name:
ANRIL
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
caspase-3-dependent apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of lncRNA were determined by Reverse transcription and real-time quantitative PCR . Those of protein were by Western blot analysis. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
oral squamous cell carcinoma
Tissue/Cell:
tissue and cell line (OSCC3, SCC4, HSC3,CAL27,A2780)
Other information
Title:
Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells.
Journal:
Sci Rep
Published:
2017
PubMed ID:
29176691