ncRNA basic information
ncRNA ID:
ENSG00000214049
ncRNA Database:
Ensembl
ncRNA Name:
UCA1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
SF1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
UCA1 expression in tumor tissues and cells was tested by qRT-PCR. MTT, flow cytometry and caspase-3 activity analysis were explored to evaluate the CDDP sensitivity in OSCC cells. Western blot analysis was used to measure BCL2, Bax and SF1 protein expression. Luciferase reporter assay was conducted to investigate the molecular relationship between UCA1, miR-184, and SF1. Nude mice model was used to confirm the functional role of UCA1 in CDDP resistance in vivo.
Drug Response:
resistant
Cancer basic information
Cancer:
oral squamous cell carcinoma
Tissue/Cell:
tissue and cell line ( Tca8113, TSCCA, CAL-27, SCC-9,Tca8113-CDDP,TSCCA-CDDP)
Other information
Title:
LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression.
Journal:
Cancer Med
Published:
2017
PubMed ID:
29125238