ncRNA basic information
ncRNA ID:
ENST00000605570.1
ncRNA Database:
Ensembl
ncRNA Name:
AK001796
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis was performed to monitor the differences in the expression of AK001796 in cisplatin-resistant (A549/DDP) cells and parental A549 cells. Cellular sensitivity to cisplatin and cell viability were examined using an MTT assay. Cell apoptosis and cell cycle distribution were measured using flow cytometry. The expression levels of cell cycle proteins cyclin C (CCNC), baculoviral IAP repeat containing 5 (BIRC5), cyclin-dependent kinase 1 (CDK1) and G2 and S phase-expressed 1 (GTSE1) were assessed using RT-qPCR and western blot analyses.
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549,A549/DDP)
Other information
Title:
Long non-coding RNA AK001796 contributes to cisplatin resistance of non-small cell lung cancer.
Journal:
Mol Med Rep
Published:
2017
PubMed ID:
29067469