ncRNA basic information
ncRNA ID:
ENSG00000229807
ncRNA Database:
Ensembl
ncRNA Name:
XIST
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of lncRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of lncRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. TUNEL staining was used to detect apoptotic cell death.
Drug Response:
resistant
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
cell line (A549)
Other information
Title:
LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis.
Journal:
Cell Cycle
Published:
2017
PubMed ID:
28961027