ncRNA basic information
ncRNA ID: ENSG00000130600
ncRNA Database: Ensembl
ncRNA Name: H19
ncRNA Type: lncRNA
ncRNA Expression: up-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: Fas
ncRNA Pathway: FADD/Caspase 8/Caspase 3 Signaling Pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00515 (APRD00359)
Drug Name: Cisplatin
Drug Method: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the relative expression of H19 and miR-675 in normal (GES-1) and gastric cancer cell lines (SGC-7901, SGC-7901/DDP) as well as in tumor tissues. Gain and loss of function approaches were carried out to investigate the potential roles of H19/miR-675 in cell proliferation and apoptosis. Moreover, Fas associated via death domain (FADD) was validated to be the target of miR-675 via luciferase reporter assay. Western blotting was used to evaluate the protein expression of related signaling pathway.
Drug Response: resistant
Cancer basic information
Cancer: stomach cancer
Tissue/Cell: cell line ( SGC-7901,SGC-7901/DDP, GES-1)
Other information
Title: Long Noncoding RNA H19/miR-675 Axis Promotes Gastric Cancer via FADD/Caspase 8/Caspase 3 Signaling Pathway.
Journal: Cell Physiol Biochem
Published: 2017
PubMed ID: 28848149