ncRNA basic information
ncRNA ID:
ENSG00000260944
ncRNA Database:
Ensembl
ncRNA Name:
ODRUL
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
PCR
ncRNA Target Gene:
MMP2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of lncRNA were determined by PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of lncRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of lncRNAs. The CCK-8 assay was used to monitor the growth of the cells. A wound healing assay was performed to examine the capacity of cell migration. Xenograft transplantation was used to test the role of ODRUL .
Drug Response:
resistant
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (SaoS2, HOS, U2-OS, MG63, and 143B)
Other information
Title:
LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis.
Journal:
Mol Ther
Published:
2017
PubMed ID:
28750740