ncRNA basic information
ncRNA ID:
ENSG00000245532
ncRNA Database:
Ensembl
ncRNA Name:
NEAT1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
HMGA2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00544 (APRD00516, EXPT03204)
Drug Name:
Fluorouracil
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by transwell migration and invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MDA-MB-231, T-47-D and ZR-75-1)
Other information
Title:
The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer.
Journal:
Int J Biol Macromol
Published:
2017
PubMed ID:
28720546