ncRNA basic information
ncRNA ID:
ENSG00000258609
ncRNA Database:
Ensembl
ncRNA Name:
ROR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of lncRNAs. TUNEL staining was used to detect apoptotic cell death. Tumor formation in nude mice was used to test the role of ROR .
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF7, BT474, MDA-MB-435, and MDA-MB-231)
Other information
Title:
Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer.
Journal:
Tumour Biol
Published:
2017
PubMed ID:
28635401