ncRNA basic information
ncRNA ID: MI0003188
ncRNA Database: miRBase
ncRNA Name: miR-503
ncRNA Type: miRNA
ncRNA Expression: down-regulated
ncRNA Method: qRT-PCR
ncRNA Target Gene: PI3K
ncRNA Pathway: PI3K/AKT signaling pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00515 (APRD00359)
Drug Name: Cisplatin
Drug Method: To investigate the relationship between miR-503 expression and the sensitivity of ovarian cancer cells to cisplatin, the cells were transfected with miR-503 mimics/inhibitors. The relative expression of miR-503 RNA and its targeted gene PI3K mRNA were detected by real-time PCR (RT-PCR). Western blot was used to measure relevant protein levels. Flow cytometry and CCK-8 assay were used to analyze cell proliferation and apoptosis.
Drug Response: resistant
Cancer basic information
Cancer: ovarian cancer
Tissue/Cell: cell line (SKOV3,SKOV3/DDP)
Other information
Title: Downregulation of miR-503 contributes to the development of drug resistance in ovarian cancer by targeting PI3K p85.
Journal: Arch Gynecol Obstet
Published: 2018
PubMed ID: 29327155