ncRNA basic information
ncRNA ID:
ENST00000558952
ncRNA Database:
Ensembl
ncRNA Name:
CRNDE-205
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP70 cells. Expression levels of these lncRNAs were then verified in SKOV3 and SKOV3/DDP cells. Quantitative polymerase chain reaction was conducted to identify the lncRNA most downregulated, which was then synthesized and transfected into CP70 cells. To assess the viability and migration ability of these transfected CP70 cells, methyl thiazolyl tetrazolium and Transwell assays were carried out. In addition, expression levels of apoptosis-related proteins were examined by western blotting.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (A2780, CP70, SKOV3, and SKOV3/DDP)
Other information
Title:
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells.
Journal:
Genet Mol Res
Published:
2017
PubMed ID:
28128423