ncRNA basic information
ncRNA ID:
MI0000095
ncRNA Database:
miRBase
ncRNA Name:
miR-93
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
PTEN/AKT signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
MicroRNA array was used to the different express between OVCAR3/CDDP and SKOV3/CDDP. The target genes of miRNA were predicted by two computer-aided algorithms.The expression levels of miRNA were determined by Quantitative RT-PCR and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
tissue and cell line ( OVCAR3, SKOV3 )
Other information
Title:
Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells.
Journal:
FEBS Lett
Published:
2012
PubMed ID:
22465665