ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Tissue samples were collected from NSCLC patients, and total RNA was isolated for assessment of HOTAIR expression and drug resistance status. MTT assays, tumor sphere formation assays, and western blot were performed to cytologically determine the relationship between HOTAIR expression and cisplatin resistance, as well as to elucidate the potential molecular mechanism involved.
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A459,A549/CDDP)
Other information
Title:
Elevated HOTAIR expression associated with cisplatin resistance in non-small cell lung cancer patients.
Journal:
J Thorac Dis
Published:
2016
PubMed ID:
28066612